Analysis of the steroid, nandrolone, in urine Free Essay Example, 1000 words

If GC/MS in electron ionization is used exclusively in selected ion monitoring, it can result in misidentification and poor quantification because of interference from same m/z value compounds in the matrix. One method to improve selectivity and sensitivity of the test is to use positive chemical ionization with ammonia as reagent (Wuest, 2004). Instrumentation The analysis of the metabolites can be performed by gas chromatography–mass spectrometry. The method of analysis allows both quantification and qualitative analysis. The analyses are performed using a gas chromotography equipped with autosampler and coupled with mass-selective detector. A computer and ChemStation software are employed for instrument control and data processing. Gas chromatography separation can be achieved on 5% phenyl–95% dimethyl-polysiloxane or Phenomenex column. The dimensions of the column which are usually employed are 30 m x 0.25 mm with 0.25-Â µm film thickness. The operation is done with helium inlet pressure of 103 kPa. the temperature programming which will be usually followed is 100 Â °C for 1 min, increased at 16 Â °C/min to 220 Â °C, increased at 3.80 Â °C/min to 270 Â °C, and held for 3 min. We will write a custom essay sample on Analysis of the steroid, nandrolone, in urine or any topic specifically for you Only $17.96 $11.86/pageorder now 1 micro liter of samples of urine should be injected at 270 degree at one minute into as in the splitless mode split-splitless injection port with an inner glass liner which is silanized. the transfer line is heated to 280 degrees. The source of ion is operated at 70eV in the electron impact mode. The analysis should be performed in single-ion monitoring mode. For [12C] nandrolone, ions m/z 420, 405, and 315 must be used and for [13C] nandrolone, m/z 422, 407, and 317 must be used. For [12C] nandrolone, m/z 405 can be used for quantification and 407 for [13C] nandrolone (Baume et al, 2004). Figure. 3. Mass spectra of 12C-NA (A) and 13C-NA (B) bis-trimethylsilyl derivatives (Baume et al, 2004). Along with performance of these qualitative and quantitative tests, specific gravity of the urine sample also must be checked. If the value is less than 1.02, then no correction is required. If the value is above 1.02, a correction threshold must be made using the formula (WADA, 2004). Threshold1.020 ng/mL= (Specific gravity of the Sample – 1) / (1.020 – 1) * 2 ng/mL If steroids are analysed by positive chemical ionisation, the GC/MS system must be able to provide precise control of GC carrier gas, accurate and reproducible temperature ramping of the oven, stable and controllable source of ion and temperatures of quadrupole and precise and stable reagent gas control.

Personal Career Development Plan Essay - 1401 Words

PERSONAL CAREER DEVELOPMENT PLAN Ruth Ann Loyd Jacksonville University Professional Nursing NUR352SI Kathleen Kavanagh September 4, 2013 Abstract My personal career development plan consists of short and long-term goals advancements in my education towards a MSN degree and moving into the nurse practitioner role. It contains the plans on how I intend to transition into that role along with the responsibilities, necessary education and license requirements. I have also listed the pros and cons of being a nurse practitioner and its potential liabilities. Study and time management plans are included along with stress reduction strategies. PERSONAL CAREER DEVELOPMENT PLAN My nursing career started as a dream, a dream I needed to†¦show more content†¦My selected mentor is Jerry Martin RN, BSN. He is a co-worker that has inspired me to return to school and that any dream is obtainable. Jerry has a degree in biology and was working as a ward clerk in our ER when I met him. He has a degree in biology and worked in finance before working at the hospital. Jerry states† I was unhappy with my career in finance and I realized I had drifted a long way from my education and my core belief. During a conference a guest speaker said â€Å"true happiness is found when you find the one thing you would do in life even if you did not get paid for it†. That was my â€Å"aha† moment.† G.M. Martin (personal communication, September 3,2013) Jerry entered nursing school in 2006 and graduated with a BSN in 2011. He is currently working toward a MSN and striving to be a FNP. He is a great nurse and it is a privilege to have him as a co-worke r and my mentor. After obtaining a BSN through Jacksonville University, I will enroll in an online nurse practitioner program. Once I receive my degree and am licensed as a NP, I will search for a job working with inpatient pediatric patients. A nurse practitioner is an advanced practice nurse that has received additional training and education of that beyond a RN. They help with all aspects of patient care. They can work in inpatient and outpatient care. A NP educates patients about preventative care and their prescribed treatments. They can also preform independently or as part ofShow MoreRelatedPersonal And Career Development Plan1309 Words   |  6 Pages Assignment 6 Case Study Personal and Career Development Plan Murali Krishna Chagarlamudi CAR 100 600D – Career Planning and Development Virginia International University Dr. Theresa Poussaint April 20, 2016 According to Maxwell and Knox (2009), academics and practitioners have extolled the potential benefits of having a well-managed cooperate brand. They have also acknowledged that corporate branding brings new challenges that cannot be readily addressed within a traditional marketingRead MoreDevelopment Plan For The Professional And The Academic Field1521 Words   |  7 PagesDevelopment Needs Analysis Introduction Why a development planning is important to a learner who wants to succeed in the professional and the academic field? A development plan is defined as a structured and supported process commenced by learners to consider their own learning, performance and achievement and to plan for their personal, educational and career development. In another words, a development plan is an inclusive process, which is opened to all learners, in all higher education provisionRead MoreMy Nursing Philosophy : My Philosophy Of Nursing Practice1074 Words   |  5 Pageswell as through engaging in research to generate new knowledge which sustains nursing as a profession. 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Gun Violence in America Free Essays

Gun violence in America is not at all as bad as it is in Sierra Leone and other countries with war and little law enforcement as we read about in the book a long way gone. In the book the main character Ishmael discovers that America is not at all like he heard through rap songs. When he moves to America and tells his story of being a soldier and killing people the people he talks to about it think that it is cool and Ishmael states in the book â€Å"violence in America is romanticized. We will write a custom essay sample on Gun Violence in America or any similar topic only for you Order Now I do agree with this statement that we do make war look easy and fun through movies and video games. We do not understand what it is like to be in a war and witness killing and bloodshed every day. Gun violence in America is not understood by very many people most people blame guns for killing people but it is not the guns that kill people it is people that kill people either by accident or on purpose in a murder. This is seen in the statistics â€Å"gun violence has gone up from 10,000 victims in 1975 to 15,000 victims in 1995.† This information proves that violence has gone up with the increases in gangs and the lessening of guns in households and teaching of gun safety. Also, 98% of gang homicides involve guns. Gun violence in America has been on the increase, since 1975 when there were less than 27 gun related death. In 1999 it increased to 80 deaths every day. http://www .gun-control-network.org/GF01.htm. Gun deaths are not only homicides nearly 58% are suicide. Another statistic is one hundred cities with populations of 250,000 or more have reported a tremendous amount of gang activity. When there is gang activity there is an increased amount of homicides. There are so many active gangs in the United States. They range from the crypts to the bloods and they are known worldwide. These are not the only gangs there are many more not mentioned. However, 94% of gang members are male and only 6% are female. It’s not a surprise that 77% of murdered juveniles were killed by a gun. With the increased gang activity in the United States 39% of households have a gun. In the United States many people have a fear of guns but guns aren’t something to fear. If everybody had a gun and knew how to use it then we would all have protection from people that want to harm us with a gun. If guns were outlawed then there would be riots and the murder rate would go up because the people that want to do good with them would not be able to protect themselves and others, the people that want to harm others with a gun would not turn in their gun and would be able to harm other people with little fear. Violence is seen everywhere in today’s society on the news, movies, videogames, and in our lives. This violence lends the illusion to our society today that violence is cool and fun and only portrays the faà §ade that our society has created. The general public does not even begin to understand the traumatic images that our soldiers have come back with and we think that the war we see on the news is like the movies that we watch on T.V. but we cannot begin to imagine. How to cite Gun Violence in America, Essay examples